Novel Morphologic Findings in PLAG1-Rearranged Soft Tissue

Novel Morphologic Findings in PLAG1-Rearranged Soft Tissue

Proteomic profiling of soft tissue sarcomas with SWATH mass spectrometry

Soft tissue sarcomas (STS) are a group of rare and heterogeneous cancers. While large-scale genomic and epigenomic profiling of STS have been undertaken, proteomic analysis has thus far been limited. Here we utilise sequential window acquisition of all theoretical fragment ion spectra mass spectrometry (SWATH-MS) for proteomic profiling of formalin fixed paraffin embedded (FFPE) specimens from a cohort of STS patients (n = 36) across four histological subtypes (leiomyosarcoma, synovial sarcoma, undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma).
We quantified 2951 proteins across all cases and show that there is a significant enrichment of gene sets associated with smooth muscle contraction in leiomyosarcoma, RNA splicing regulation in synovial sarcoma and leukocyte activation in undifferentiated pleomorphic sarcoma.
We further identified a subgroup of STS cases that have a distinct expression profile in a panel of proteins, with worse survival outcomes when compared to the rest of the cohort. Our study highlights the value of comprehensive proteomic characterisation as a means to identify histotype-specific STS profiles that describe key biological pathways of clinical and therapeutic relevance; as well as for discovering new prognostic biomarkers in this group of rare and difficult-to-treat diseases.

Novel Morphologic Findings in PLAG1-Rearranged Soft Tissue Tumors

Oncogenesis in PLAG1-rearranged tumors often results from PLAG1 transcription factor overexpression driven by promoter-swapping between constitutively expressed fusion partners. PLAG1-rearranged tumors demonstrate diverse morphologies. This study adds to this morphologic heterogeneity by introducing two tumors with PLAG1 rearrangements that display distinct histologic features. The first arose in the inguinal region of a 3-year-old, appeared well-circumscribed with a multinodular pattern, and harbored two fusions: ZFHX4-PLAG1 and CHCHD7-PLAG1.
The second arose in the pelvic cavity of a 15-year-old girl, was extensively infiltrative and vascularized with an adipocytic component, and demonstrated a COL3A1-PLAG1 fusion. Both showed low-grade cytomorphology, scarce mitoses, no necrosis, and expression of CD34 and desmin. The ZFHX4-/CHCHD7-PLAG1-rearranged tumor showed no evidence of recurrence after 5 months.
By contrast, the COL3A1-PLAG1-rearranged tumor quickly recurred following primary excision with positive margins; subsequent re-excision with adjuvant chemotherapy resulted in no evidence of recurrence after two years. While both tumors show overlap with benign and malignant fibroblastic and fibrovascular neoplasms, they also display divergent features. These cases highlight the importance of appropriate characterization in soft tissue tumors with unusual clinical and histologic characteristics. This article is protected by copyright. All rights reserved.
curecancernowfoundation
curecancernowfoundation

CancerSeq™ Plus Paraffin Tissue Tumor Sections: Thyroid

T2235265-SC 5 curls
EUR 818

CancerSeq™ Plus Paraffin Tissue Tumor Section: Lung

T2235152-SC 5 curls
EUR 818

Paraffin Tissue Section - Human Bone Tumor

T2235023 5 slides
EUR 262

Paraffin Tissue Section - Human Lung Tumor

T2235152 5 slides
EUR 262

Paraffin Tissue Section - Human Skin Tumor

T2235218 5 slides
EUR 262

Paraffin Tissue Section - Human Brain Tumor

T2235035 5 slides
EUR 262

Paraffin Tissue Section - Human Colon Tumor

T2235090 5 slides
EUR 262

Paraffin Tissue Section - Human Liver Tumor

T2235149 5 slides
EUR 262

Matched Pair - Paraffin Tissue Sections - Human Primary Tumor and Normal (PP): Stomach

T8235248-PP 5 slides x2
EUR 383

Paraffin Tissue Section - Human Breast Tumor

T2235086 5 slides
EUR 262

Paraffin Tissue Section - Human Kidney Tumor

T2235142 5 slides
EUR 262

Paraffin Tissue Section - Human Testis Tumor

T2235260 5 slides
EUR 262

Paraffin Tissue Section - Human Tonsil Tumor

T2235268 5 slides
EUR 262

Paraffin Tissue Section - Human Adipose Tumor

T2235003 5 slides
EUR 262

Paraffin Tissue Section - Human Adrenal Tumor

T2235004 5 slides
EUR 262

Paraffin Tissue Section - Human Bladder Tumor

T2235010 5 slides
EUR 262

Paraffin Tissue Section - Human Kidney Tumor: Wilms' Tumor

T2235142-7 5 slides
EUR 262

Paraffin Tissue Section - Human Appendix Tumor

T2235006 5 slides
EUR 262

Paraffin Tissue Section - Human Pancreas Tumor

T2235188 5 slides
EUR 262

Paraffin Tissue Section - Human Prostate Tumor

T2235201 5 slides
EUR 262

Paraffin Tissue Section - Human Abdominal Tumor

T2235001 5 slides
EUR 262

Dog Adipose Tissue paraffin Sections

DP-103 10 slides
EUR 240

Cat Adipose Tissue Paraffin Sections

FP-103 10 slides
EUR 240

Rat Adipose Tissue Paraffin Sections

RP-103 10 slides
EUR 266

Paraffin Tissue Section - Human Parathyroid Tumor

T2235189 5 slides
EUR 262

Paraffin Tissue Section - Human Gallbladder Tumor

T2235118 5 slides
EUR 262

Human Adipose Tissue Paraffin Sections

HP-103 10 slides
EUR 228

Paraffin Tissue Section - Human Uterus Cervix Tumor

T2235275 5 slides
EUR 262

Rat WS Adipose Tissue Paraffin Sections

RP-103-WS 10 slides
EUR 266

Paraffin Tissue Section - Human Pancreas Tumor: Islet Cell Tumor

T2235188-3 5 slides
EUR 262

Paraffin Tissue Section - Human Adipose Tumor: Lipoma

T2235003-1 5 slides
EUR 262

Paraffin Tissue Section - Human Angioma: Glomus Tumor

T2235011-2 5 slides
EUR 262

Paraffin Tissue Section - Human Bone Tumor: Chondroma

T2235023-2 5 slides
EUR 262

Matched Pair - Paraffin Tissue Sections - Human Primary and Matched Metastatic Tumor (PM): Stomach

T8235248-PM 5 slides x2
EUR 639

Paraffin Tissue Section - Human Adrenal Tumor: Adenoma

T2235004-1 5 slides
EUR 262

Paraffin Tissue Section - Human Brain Tumor: Epndymoma

T2235035-6 5 slides
EUR 262

Paraffin Tissue Section - Human Testis Tumor: Seminoma

T2235260-3 5 slides
EUR 262

Paraffin Tissue Section - Human Brain Tumor: Gliocytoma

T2235035-7 5 slides
EUR 262

Paraffin Tissue Section - Human Brain Tumor: Meningioma

T2235035-9 5 slides
EUR 262

Paraffin Tissue Section - Human Skin Tumor: Fibrosarcoma

T2235218-2 5 slides
EUR 262

Paraffin Tissue Section - Human Tumor Cell Line: MCF-7

T2255830 5 slides
EUR 262

Paraffin Tissue Section - Human Adrenal Tumor: Myelolipoma

T2235004-3 5 slides
EUR 262

Paraffin Tissue Section - Human Bone Tumor: Chondrosarcoma

T2235023-3 5 slides
EUR 262

Paraffin Tissue Section - Human Breast Tumor: Fibroadenoma

T2235086-1 5 slides
EUR 262

Paraffin Tissue Section - Human Lung Tumor: Adenocarcinoma

T2235152-1 5 slides
EUR 262

Paraffin Tissue Section - Human Colon Tumor: Adenocarcinoma

T2235090-1 5 slides
EUR 262

Paraffin Tissue Section - Human Liver Tumor: Adenocarcinoma

T2235149-1 5 slides
EUR 262

Paraffin Tissue Section - Human Bone Tumor: Synovial Sarcoma

T2235023-8 5 slides
EUR 262

Paraffin Tissue Section - Human Bone Tumor: Giant Cell Tumor, Grade I-II

T2235023-6 5 slides
EUR 262

Paraffin Tissue Section - Human Appendix Tumor: Adenocarcinoma

T2235006-1 5 slides
EUR 262

Paraffin Tissue Section - Human Brain Tumor: Craniopharyngioma

T2235035-4 5 slides
EUR 262

Paraffin Tissue Section - Human Pancreas Tumor: Adenocarcinoma

T2235188-1 5 slides
EUR 262

Paraffin Tissue Section - Human Prostate Tumor: Adenocarcinoma

T2235201-1 5 slides
EUR 262

Paraffin Tissue Section - Human Brain Tumor: Ependymal Glioma

T2235035-5 5 slides
EUR 262

Paraffin Tissue Section - Human Skin Tumor: Malignant Melanoma

T2235218-3 5 slides
EUR 262

Paraffin Tissue Section - Human Bone Tumor: Myeloma, Plasmacytic

T2235023-7 5 slides
EUR 262

Paraffin Tissue Section - Human Brain Tumor: Meningioma (Fibrous)

T2235035-10 5 slides
EUR 262

Paraffin Tissue Section - Human Breast Tumor: Lobular carcinoma

T2235086-3 5 slides
EUR 262

Paraffin Tissue Section - Human Colon Tumor: Adenocarcinoma, MSH

T2235090MSH 5 slides
EUR 771

Paraffin Tissue Section - Human Colon Tumor: Adenocarcinoma, MSS

T2235090MSS 5 slides
EUR 550

Paraffin Tissue Section - Human Abdominal Tumor: Neuofibromatosis

T2235001-7 5 slides
EUR 262

Paraffin Tissue Section - Human Brain Tumor: Meningioma (Necrotic)

T2235035-11 5 slides
EUR 262

Paraffin Tissue Section – Human Breast Tumor, BRCA Characterized

T2235086BRCA 5 slides
EUR 550

Paraffin Tissue Section - Human Rectum Tumor: Adenocarcinoma, MSS

T2235206MSS 5 slides
EUR 550

Paraffin Tissue Section - Human Uterus Tumor: Adenocarcinoma, MSS

T2235274MSS 5 slides
EUR 550

Paraffin Tissue Section - Human Lung Tumor: Large Cell Carcinoma

T2235152-6 5 slides
EUR 262

Paraffin Tissue Section - Human Lung Tumor: Small Cell Carcinoma

T2235152-9 5 slides
EUR 262

Paraffin Tissue Section - Human Tonsil Tumor: Lymphoma of Tonsil

T2235268-1 5 slides
EUR 262

Paraffin Tissue Section - Human Colon Tumor: Adenocarcinoma (Ulcer)

T2235090-3 5 slides
EUR 262

Paraffin Tissue Section - Human Stomach Tumor: Adenocarcinoma, MSS

T2235248MSS 5 slides
EUR 550

Paraffin Tissue Section Panel - Human Tumor Same Tumor Type, Different Donors (5 tissues)

T8235086 5 slides
EUR 416

Paraffin Tissue Section Panel - Human Tumor, Same Tumor Type, Different Donors (5 tissues)

T8235090 5 slides
EUR 446

Paraffin Tissue Section Panel - Human Tumor, Same Tumor Type, Different Donors (5 tissues)

T8235106 5 slides
EUR 446

Paraffin Tissue Section Panel - Human Tumor, Same Tumor Type, Different Donors (5 tissues)

T8235142 5 slides
EUR 446

Paraffin Tissue Section Panel - Human Tumor, Same Tumor Type, Different Donors (5 tissues)

T8235149 5 slides
EUR 446

Paraffin Tissue Section Panel - Human Tumor, Same Tumor Type, Different Donors (5 tissues)

T8235152 5 slides
EUR 446

Paraffin Tissue Section Panel - Human Tumor, Same Tumor Type, Different Donors (5 tissues)

T8235183 5 slides
EUR 446

Paraffin Tissue Section Panel - Human Tumor, Same Tumor Type, Different Donors (5 tissues)

T8235206 5 slides
EUR 446

Paraffin Tissue Section Panel - Human Tumor, Same Tumor Type, Different Donors (5 tissues)

T8235248 5 slides
EUR 446

Paraffin Tissue Section Panel - Human Tumor, Same Tumor Type, Different Donors (5 tissues)

T8235274 5 slides
EUR 446

Paraffin Tissue Section - Human Parotid Tumor: Pleomorphic Adenoma

T2235190-5 5 slides
EUR 262

Paraffin Tissue Section - Human Brain Tumor: Astrocytoma Grade I

T2235035-1 5 slides
EUR 262

Paraffin Tissue Section - Human Brain Tumor: Astrocytoma Grade II

T2235035-2 5 slides
EUR 262

Paraffin Tissue Section - Human Uterus Cervix Tumor, HPV positive

T2235275HPV 5 slides
EUR 550

Paraffin Tissue Section - Human Uterus Cervix Tumor, HPV positive

T2235275HPV+ 5 slides
EUR 646.8
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

DNA Methylation in Ovarian Tumors-a Comparison Between Fresh Tissue and FFPE Samples

Among women, ovarian cancer (OC) is one of the most severe forms of malignancy, accounting for a low 5-year survival rate, of approximately 52%. Early symptoms are unspecific and hence hard to detect. The origin of OC and its subtypes are still unclear, underlying the need for efficient diagnostic biomarkers. In that regard, epigenetics studies are emerging in cancer diagnostics, with encouraging outcomes.
  • Among them, DNA methylation profiling has shown that the origins of the cancer epigenome are associated with molecular factors that are crucial to carcinogenesis, such as regulation of oncogenes and tumor suppressors.
  • Furthermore, those events have been detected in abnormal cell morphology before neoplastic formation, indicating its potential crucial use in the OC diagnostics in the future. Nonetheless, studies are limited, and whether methylation analysis can be performed optimally in formalin-fixed paraffin-embedded (FFPE) preparations of OC cases is still elusive.
  • In the present report, we investigated the performance of DNA methylation analysis in FFPE samples, compared to their matched fresh frozen tissue in a small cohort of OC samples.
  • We found that the overall DNA methylation profile in FFPE tissue showed high concordance to that found in fresh frozen tissue, and accounting for the small cohort size, the differentially methylated sites found primarily in frozen tissue, compared to benign samples, were also reproducible in FFPE.
  • Overall, by using samples from our current clinical setting of tissue preservation, these preliminary observations might provide insights into the clinical use of FFPE tissues in methylation studies without critically compromising the outcome.

An atlas of the tissue and blood metagenome in cancer reveals novel links between bacteria, viruses and cancer

Background: Host tissue infections by bacteria and viruses can cause cancer. Known viral carcinogenic mechanisms are disruption of the host genome via genomic integration and expression of oncogenic viral proteins. An important bacterial carcinogenic mechanism is chronic inflammation. Massively parallel sequencing now routinely generates datasets large enough to contain detectable traces of bacterial and viral nucleic acids of taxa that colonize the examined tissue or are integrated into the host genome. However, this hidden resource has not been comprehensively studied in large patient cohorts.
Methods: In the present study, 3025 whole-genome sequencing datasets and, where available, corresponding RNA-seq datasets are leveraged to gain insight into novel links between viruses, bacteria, and cancer. Datasets were obtained from multiple International Cancer Genome Consortium studies, with additional controls added from the 1000 genome project.
A customized pipeline based on KRAKEN was developed and validated to identify bacterial and viral sequences in the datasets. Raw results were stringently filtered to reduce false positives and remove likely contaminants.
Results: The resulting map confirms known links and expands current knowledge by identifying novel associations. Moreover, the detection of certain bacteria or viruses is associated with profound differences in patient and tumor phenotypes, such as patient age, tumor stage, survival, and somatic mutations in cancer genes or gene expression profiles.
Conclusions: Overall, these results provide a detailed, unprecedented map of links between viruses, bacteria, and cancer that can serve as a reference for future studies and further experimental validation. Video Abstract.

High density esophageal cancer tissue array

ES208 each
EUR 546
Description: High density esophageal cancer tissue array, with normal tissue, grade and TNM, 69 cases/208 cores, replaced by ES208a

Esophageal cancer and adjacent tissue array

ES722 each
EUR 270
Description: Esophageal cancer and adjacent tissue array, with stage and grade info, 30 cases/72 cores, replacing BC02023

Esophageal cancer tissue array with esophagus tissue as control

ES482a each
EUR 138
Description: Esophageal cancer tissue array with esophagus tissue as control, including TNM, clinical stage and pathology grade, 48 cases/ 48 cores, replacing ES482

Esophageal squamous cell carcinoma tissue array

ES802 each
EUR 270
Description: Esophageal squamous cell carcinoma tissue array, grade I-III, 40 cases/80 cores, no overlaps with ES801

Esophagus Tumor Tissue Array - 12 cases of esophageal cancer, each in duplicates, paired with adjacent normal tissues

Z7020027 5 slides
EUR 1657.2
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Esophageal disease (progression) spectrum tissue array

ES2081 each
EUR 546
Description: Esophageal disease (progression) spectrum tissue array, 103 cases/208 cores

Esophageal cancer and adjacent normal tissue array

ES8010 each
EUR 306
Description: Esophageal cancer and adjacent normal tissue array, with TNM and grade info, 40 cases/80 cores, replacing ES801

Esophageal cancer tissue array for antibody screening

ES1002 each
EUR 306
Description: Esophageal cancer tissue array for antibody screening, including TNM, clinical stage and pathology grade, 50 cases/100 cores

Esophageal cancer tissue array with normal tissues from autopsy

ES811 each
EUR 306
Description: Esophageal cancer tissue array with normal tissues from autopsy, 40 cases/80 cores, plus grade and stage information

Human Cancer Tissue Preparation Buffer 1: Esophageal Tumor Cells

9-80024 1 x 100 ml Ask for price

Esophageal cancer tissue array with matched or unmatched normal adjacent tissues (18 cases/48 cores) with stage and grade info

ES481 each
EUR 198
Description: Esophageal cancer tissue array with matched or unmatched normal adjacent tissues (18 cases/48 cores) with stage and grade info

Esophagus tissue and esophagus cancer tissue array

BN02014a each
EUR 306
Description: Esophagus tissue and esophagus cancer tissue array, including pathology grade, TNM and clinical stage, 80 cases/80 cores, replacing BN02014

Esophageal squamous cell carcinoma Tissue block

48 1 unit Ask for price

Multiple Tumor Tissue Array - Kidney, Colon, Esophagus, Liver, Rectum and Stomach tumors, plus 12 tumor/normal pairs

T8235715d-2 2 slides
EUR 325

Multiple Tumor Tissue Array - Kidney, Colon, Esophagus, Liver, Rectum and Stomach tumors, plus 12 tumor/normal pairs

T8235715d-5 5 slides
EUR 667

Esophagus cancer tissue array

ES243 each
EUR 270
Description: Esophagus cancer tissue array, with normal tissue, including TNM and pathology grade, 2 serial sections, 24 cases/48 cores

Esophagus cancer tissue array

ES781 each
EUR 306
Description: Esophagus cancer tissue array, including pathology grade, TNM and clinical stage, 16 cases/78 cores, replacing BC02111

Esophagus cancer and esophagus tissue array

ES208a each
EUR 546
Description: Esophagus cancer and esophagus tissue array, with metastatic cancer, including pathology grade, TNM and clinical satge, 64 cases/192 cores, replacing ES208

Esophagus cancer with esophagus tissue array

ES1501 each
EUR 258
Description: Esophagus cancer with esophagus tissue array, including pathology grade, TNM and clinical stage, 75 cases/150 cores

Esophagus carcer test tissue array

T023 each
EUR 66
Description: Esophagus carcer test tissue array, with normal esophagus tissue as control, including TNM, clinical stage and pathology grade, 2 serial sections, 6 cases/24 cores

Human Cancer PrimaCell1: Esophageal Tumor Cells

2-96024 1 Kit Ask for price

Esophagus cancer tissue array with normal tissue

T021b each
EUR 48
Description: Esophagus cancer tissue array with normal tissue, including TNM and pathology grade, 6 cases/24 cores, replacing T021a

Esophagus Tumor Tissue Array - 48 cases of normal, inflammatory and cancerous (different grades & stages) tissues of the

Z7020030 5 slides
EUR 1657.2
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Human Cancer Tissue Preparation Buffer 7: Esophageal Fibroblasts

9-80030 1 x 100 ml Ask for price

Esophagus cancer and normal tissue array

ES805 each
EUR 306
Description: Esophagus cancer and normal tissue array, with grade and stage data, 40 cases/80 cores

Esophagus cancer and normal tissue array

ES808 each
EUR 306
Description: Esophagus cancer and normal tissue array, with TNM and grade info, 78 cases/80 cores

Esophagus cancer and normal tissue array

T021c each
EUR 48
Description: Esophagus cancer and normal tissue array, inclduing pathology grade, TNM and clinical stage, 6 cases/24 cores, replacing T021b

Rat Esophagus Tissue Preparation Buffer 1: Normal Esophageal Epithelial Cells

9-80243 1 x 100 ml Ask for price

Esophagus cancer with normal tissue array

T022d each
EUR 78
Description: Esophagus cancer with normal tissue array, including pathology grade, TNM and clinical stage, 12 cases/24 cores, replacing T022c

Human Esophagus Tissue Preparation Buffer 1: Normal Esophageal Epithelial Cells

9-80055 1 x 100 ml Ask for price

Mouse Esophagus Tissue Preparation Buffer 1: Normal Esophageal Epithelial Cells

9-80149 1 x 100 ml Ask for price

Rat Esophagus Tissue Preparation Buffer 2: Normal Esophageal Smooth Muscle Cells

9-80244 1 x 100 ml Ask for price

Esophagus cancer tissue array with normal tissue as control

ES1021 each
EUR 306
Description: Esophagus cancer tissue array with normal tissue as control, including TNM, clinical stage and pathology grade, 102 cases/ 102 cores

Esophagus cancer with adjacent normal esophagus tissue array

BC02012a each
EUR 168
Description: Esophagus cancer with adjacent normal esophagus tissue array, including pathology grade, TNM and clinical stage, 72 cases/72 cores, replacing BC02012

Human Esophagus Tissue Preparation Buffer 2: Normal Esophageal Smooth Muscle Cells

9-80056 1 x 100 ml Ask for price

Mouse Esophagus Tissue Preparation Buffer 2: Normal Esophageal Smooth Muscle Cells

9-80150 1 x 100 ml Ask for price

Esophagus adenocarcinoma and normal tissue array

ES8011b each
EUR 306
Description: Esophagus adenocarcinoma and normal tissue array, including TNM, clinical stage and pathology grade, 40 cases/80 cores (1.5mm), replacing ES8011a

Human Cancer PrimaCell1: Esophageal Tumor Cells Growth Medium

9-46024 5 x 100 ml Ask for price

Different stages of esophagus cancer with esophagus tissue array

ES807 each
EUR 306
Description: Different stages of esophagus cancer with esophagus tissue array, including pathology grade, TNM and clinical stage, 80 cases/80 cores

Esophagus cancer with matched cancer adjacent esophagus tissue array

ES1025 each
EUR 354
Description: Esophagus cancer with matched cancer adjacent esophagus tissue array, including pathology grade, TNM and clinical stage (AJCC 8.0), 51 cases/102 cores (1.5 mm).

Esophagus cancer tissue array for antibody screening

ES1001 each
EUR 306
Description: Esophagus cancer tissue array for antibody screening, including TNM, clinical stage and pathology grade, 25 cases/100 cores

Esophagus squamous cell carcinoma (grade III) tissue array

ES353a each
EUR 168
Description: Esophagus squamous cell carcinoma (grade III) tissue array, including TNM, clinical stage and pathology grade, 35 cases/35 cores, replacing ES353

Esophagus squamous cell carcinoma with normal adjacent esophagus tissue array

ES902a each
EUR 306
Description: Esophagus squamous cell carcinoma with normal adjacent esophagus tissue array, including pathology grade and TNM/Stage, 45 cases/90 cores (core size 1.5mm), replacing ES902

Soft tissue tumor tissue array

BC24011b each
EUR 270
Description: Soft tissue tumor tissue array, including TNM and clinical stage, 63 cases/63 cores, replacing BC24011a

Soft tissue tumor tissue array

SF961 each
EUR 222
Description: Soft tissue tumor tissue array, including TNM and clinical stage, 48 cases/96 cores

Esophagus squamous cell carcinoma with matched cancer adjacent tissue and esophagus lymph node tissue array

ES1505 each
EUR 258
Description: Esophagus squamous cell carcinoma with matched cancer adjacent tissue and esophagus lymph node tissue array, including pathology grade, TNM and clinical stage, 50 cases/150 cores (core size 1.5mm), replaced by ES1505a

Esophagus squamous cell carcinoma with matched cancer adjacent tissue and esophagus lymph node tissue array

ES1505a each
EUR 258
Description: Esophagus squamous cell carcinoma with matched cancer adjacent tissue and esophagus lymph node tissue array, including pathology grade, TNM and clinical stage, 50 cases/150 cores (core size 1.5mm), replacing ES1505

Esophagus squamous cell carcinoma with matched adjacent normal esophagus tissue array

ES1202 each
EUR 306
Description: Esophagus squamous cell carcinoma with matched adjacent normal esophagus tissue array, including pathology grade, TNM and clinical stage, 60 cases/120 cores, replacing ES1201

Esophagus squamous cell carcinoma with matched adjacent nomal esophagus tissue array

ES1922a each
EUR 474
Description: Esophagus squamous cell carcinoma with matched adjacent nomal esophagus tissue array, including TNM and pathology grade, 96 cases/ 192 cores (core size 1.0mm)

Esophagus squamous cell carcinoma with matched adjacent normal esophagus tissue array

ES241a each
EUR 66
Description: Esophagus squamous cell carcinoma with matched adjacent normal esophagus tissue array, inclduing pathology grade, TNM and clinical stage (reference AJCC 7th version), 6 cases/24 cores, replacing ES241

Human Esophagus Tumor Tissue Lysate

IHUESOPTLT100UG each
EUR 361
Description: Human Esophagus Tumor Tissue Lysate

Esophagus cancer and normal tissue array with TNM and grade info

ES721 each
EUR 306
Description: Esophagus cancer and normal tissue array with TNM and grade info, 24 cases/72 cores

Brain tumor tissue array

GL2083c each
EUR 546
Description: Brain tumor tissue array, including pathology grade, 192 cases/192 cores (core size 1.0mm), replacing GL2083b

Brain tumor tissue array

GL242a each
EUR 270
Description: Brain tumor tissue array, with normal tissue, 2 serial sections, 24 cases/48 cores replacing GL242

Brain tumor tissue array

GL243 each
EUR 198
Description: Brain tumor tissue array, including pathology grade, 24 cases/24 cores

Brain tumor tissue array

GL803d each
EUR 306
Description: Brain tumor tissue array,including astrocytoma, glioblastoma,oligoastrocytomas,oligodendroglioma,medulloblastoma and ependymoma,80 cases/80 cores (core size 1.5mm), replacing GL803c

Heart tumor tissue array

T301a each
EUR 48
Description: Heart tumor tissue array, with normal heart tissue, including TNM, 6 cases/24 cores, replacing T301

Brain tumor tissue array

T176a each
EUR 48
Description: Brain tumor tissue array, including pathology grade, 6 cases/24 cores, replacing T176

Advanced stage multiple esophagus cancer and normal tissue array

ES931 each
EUR 270
Description: Advanced stage multiple esophagus cancer and normal tissue array, including pathology grade, TNM and clinical stage (AJCC 8.0), 93 cases/93 cores

Esophagus cancer with matched lymph node metastasis tissue array

ES810b each
EUR 306
Description: Esophagus cancer with matched lymph node metastasis tissue array, including TNM and pathology grade, 40 cases/80 cores, replacing ES810a

Testis tumor tissue array

BC23012 each
EUR 270
Description: Testis tumor tissue array, 23 cases/63 cores

Uterus tumor tissue array

UT802a each
EUR 306
Description: Uterus tumor tissue array, including stromal and leiomyo sarcoma, endometrioid adenocarcinoma, chorionepithelioma, hydatidiform mole, clear cell carcinoma, carcinsarcoma, sarcomatoid carcinoma, with pathology grade, TNM/Stage (AJCC 8th edition), 80 cases/80 cores (cores size 1.5mm), replacing UT802

Ovarian tumor tissue array

BC110118 each
EUR 270
Description: Ovarian tumor tissue array, including pathology grade, TNM and clinical stage, 72 cases/72 cores, replacing BC11012

Lymphoma tumor tissue array

LY1501 each
EUR 258
Description: Lymphoma tumor tissue array, 75 cases/150 cores

Lymphoma tumor tissue array

LY2088a each
EUR 546
Description: Lymphoma tumor tissue array, 208 cases/208 cores replacing LY2088

Esophagus squamous cell carcinoma with matched adjacent normal esophagus tissue and metastatic carcinoma tissue array

ES2001b each
EUR 474
Description: Esophagus squamous cell carcinoma with matched adjacent normal esophagus tissue and metastatic carcinoma tissue array, including TNM and pathology grade, 120 cases/200 cores, replacing ES2001a

Total RNA - Human Tumor Tissue: Esophagus

R1235106-50 50 ug
EUR 480

Pancreatic tumor tissue array

PA806 each
EUR 306
Description: Pancreatic tumor tissue array, including TNM and clinical stage, 80 cases/ 80 cores

Soft tissue malignant tumor tissue array

T244 each
EUR 48
Description: Soft tissue malignant tumor tissue array, including TNM and clinical stage, 6 cases/24 cores

Multiple esophagus cancer test tissue array with matched or unmatched normal adjacent tissue

ES242 each
EUR 66
Description: Multiple esophagus cancer test tissue array with matched or unmatched normal adjacent tissue, 11 cases/24 cores

Total Protein - Human Tumor Tissue: Esophagus

P1235106 1 mg
EUR 357

Membrane Protein - Human Tumor Tissue: Esophagus

P3235106 0.1 mg
EUR 472

Human Cancer PrimaCell1: Esophageal Tumor Cells Growth Supplements with Serum (for 500 ml medium)

9-47024 1 Set Ask for price

Multiple organ tumor tissue array

FDA800D each
EUR 255
Description: Multiple organ tumor tissue array, including pathology grade, TNM and clinical stage, 72 cases/72 cores, replacing FDA800c

Multiple organ tumor tissue array

BC00119 each
EUR 168
Description: Multiple organ tumor tissue array, including pathology grade, TNM and clinical stage, 32 cases/32 cores

Skin malignant tumor tissue array

BC21014 each
EUR 270
Description: Skin malignant tumor tissue array, 78 cases/78 cores, replacing BC21011

Multiple organ tumor tissue array

MC2081a each
EUR 546
Description: Multiple organ tumor tissue array, including TNM, clinical stage and pathology grade, 208 cases/208 cores, replacing MC2081

Multiple organ tumor tissue array

MC2082D each
EUR 545
Description: Multiple organ tumor tissue array, including pathology grade, TNM and clinical stage, 192 cases/192 cores, replacing MC2082c

Nervous system tumor tissue array

GL961 each
EUR 306
Description: Nervous system tumor tissue array, including clinical stage and pathology grade, 48 cases/96 cores

Multiple organ tumor tissue array

MC401 each
EUR 174
Description: Multiple organ tumor tissue array, including nasopharynx squamous cell carcinoma, stomach adenocarcinoma, colon adenocarcinoma, breast carcinoma, prostate adenocarcinoma, malignant melanoma, 7 types/40 cases/40 cores (1.5mm)

Multiple organ tumor tissue array

MC485a each
EUR 222
Description: Multiple organ tumor tissue array, including pathology grade, TNM and clinical stage (lung small cell carcinoma reference AJCC 8th version, others reference AJCC 7th version), 24 cores/48 cores, replacing MC485

Multiple organ tumor tissue array

MC964b each
EUR 306
Description: Multiple organ tumor tissue array, including TNM, clinical stage and pathology grade, 96 cases/96 cores, replacing MC964a

Multiple organ tumor tissue array

TP481a each
EUR 198
Description: Multiple organ tumor tissue array, including pathology grade, TNM and clinical stage (reference AJCC 7th version), 48 cores/48 cores, replacing TP481

Peripheral nerve tumor tissue array

SO1001a each
EUR 306
Description: Peripheral nerve tumor tissue array, including TNM and clinical stage, 50 cases/100 cores, replaced by SO1001b

Peripheral nerve tumor tissue array

SO1001b each
EUR 306
Description: Peripheral nerve tumor tissue array, including TNM and clinical stage, 50 cases/100 cores, replacing SO1001a

Hodgkin's lymphoma tumor tissue array

HL481b each
EUR 270
Description: Hodgkin's lymphoma tumor tissue array, 48 cases/48 cores, replacing HL481a

Meningioma-CNS tumor tissue array

MG801b each
EUR 306
Description: Meningioma-CNS tumor tissue array, 80 cases/80 cores, replacing MG801a

Colon tumor test tissue array

T053b each
EUR 48
Description: Colon tumor test tissue array, with normal colon tissue as control, including TNM, clinical stage and pathology grade, 2 serial sections, 6 cases/12 cores, replaced by T053c

Frozen Tissue Section - Human Tumor: Esophagus

T1235106 5 slides
EUR 363

Brain tumor tissue test array

GL1003 each
EUR 306
Description: Brain tumor tissue test array, including pathology grade, 25 cases/100 cores

Bone tumor and cartilage tumor tissue array

T261b each
EUR 66
Description: Bone tumor and cartilage tumor tissue array, with normal bone and cartilage tissues, including TNM and clinical stage, 6 cases/24 cores, replacing T261a

Spleen tumor test tissue array

T321 each
EUR 48
Description: Spleen tumor test tissue array, with normal spleen control tissue, including TNM, clinical stage and pathology grade, 6 cases/24 cores

Soft tissue tumor with normal tissue array

SO801a each
EUR 306
Description: Soft tissue tumor with normal tissue array, including TNM and clinical stage, 80 cases/80 cores, replaced by SO801b

Prostate tumor test tissue array

T193a each
EUR 66
Description: Prostate tumor test tissue array, with normal prostate tissue as control, including TNM and pathology grade, 2 serial sections, 6 cases/24 cores,replaced by T193b

Genomic DNA - Human Tumor Tissue: Esophagus Tumor, from a single donor

D1235106 50 ug
EUR 562

Bone giant cell tumor tissue array

BO601 each
EUR 270
Description: Bone giant cell tumor tissue array, 30 cases/60 cores

Soft tissue tumor array with autopsy tissue

T242b each
EUR 66
Description: Soft tissue tumor array with autopsy tissue, including TNM, clinical stage, 12 cases/ 24 cores, replacing T242a

Late stage ovarian tumor tissue array

OV1921 each
EUR 546
Description: Late stage ovarian tumor tissue array, including TNM, clinical stage and pathology grade, 96 cases/192 cores

Multiple normal organ tissue with tumor tissue array

BCN911 each
EUR 306
Description: Multiple normal organ tissue with tumor tissue array, including pathology grade, TNM and clinical stage (AJCC 8.0), 91 cases/91 cores

Kidney tumor tissue array with matched tumor adjacent kidney tissue

KD2602a each
EUR 354
Description: Kidney tumor tissue array with matched tumor adjacent kidney tissue, including TNM, clinical stage and pathology grade, 65 cases/260 cores, replacing KD2602

Breast tumor tissue array (4 of 25)

BR20810 each
EUR 474
Description: Breast tumor tissue array (4 of 25), including TNM, clinical stage, pathology grade and IHC markers (ER, PR, Her-2) results,104 cases/208 cores

Breast tumor tissue array (5 of 25)

BR20811 each
EUR 474
Description: Breast tumor tissue array (5 of 25), including TNM, clinical stage, pathology grade and IHC markers (ER, PR, Her-2) results,104 cases/208 cores

Breast tumor tissue array (6 of 25)

BR20812 each
EUR 474
Description: Breast tumor tissue array (6 of 25), including TNM, clinical stage, pathology grade and IHC markers (ER, PR, Her-2) results,104 cases/208 cores

Breast tumor tissue array (7 of 25)

BR20813 each
EUR 474
Description: Breast tumor tissue array (7 of 25), including TNM, clinical stage, pathology grade and IHC markers (ER, PR, Her-2) results,104 cases/208 cores

Breast tumor tissue array (8 of 25)

BR20814 each
EUR 474
Description: Breast tumor tissue array (8 of 25), including TNM, clinical stage, pathology grade and IHC markers (ER, PR, Her-2) results,104 cases/208 cores

Breast tumor tissue array (9 of 25)

BR20815 each
EUR 474
Description: Breast tumor tissue array (9 of 25), including TNM, clinical stage, pathology grade and IHC markers (ER, PR, Her-2) results,104 cases/208 cores

Breast tumor tissue array (10 of 25)

BR20816 each
EUR 474
Description: Breast tumor tissue array (10 of 25), including TNM, clinical stage, pathology grade and IHC markers (ER, PR, Her-2) results,104 cases/208 cores

Breast tumor tissue array (11 of 25)

BR20817 each
EUR 474
Description: Breast tumor tissue array (11 of 25), including TNM, clinical stage, pathology grade and IHC markers (ER, PR, Her-2) results,104 cases/208 cores

Breast tumor tissue array (12 of 25)

BR20818 each
EUR 474
Description: Breast tumor tissue array (12 of 25), including TNM, clinical stage, pathology grade and IHC markers (ER, PR, Her-2) results,104 cases/208 cores

Breast tumor tissue array (13 of 25)

BR20819 each
EUR 474
Description: Breast tumor tissue array (13 of 25), including TNM, clinical stage, pathology grade and IHC markers (ER, PR, Her-2) results,104 cases/208 cores

Breast tumor tissue array (14 of 25)

BR20820 each
EUR 474
Description: Breast tumor tissue array (14 of 25), including TNM, clinical stage, pathology grade and IHC markers (ER, PR, Her-2) results,104 cases/208 cores

Breast tumor tissue array (15 of 25)

BR20821 each
EUR 474
Description: Breast tumor tissue array (15 of 25), including TNM, clinical stage, pathology grade and IHC markers (ER, PR, Her-2) results,104 cases/208 cores

Breast tumor tissue array (16 of 25)

BR20822 each
EUR 474
Description: Breast tumor tissue array (16 of 25), including TNM, clinical stage, pathology grade and IHC markers (ER, PR, Her-2) results,104 cases/208 cores

Breast tumor tissue array (17 of 25)

BR20823 each
EUR 474
Description: Breast tumor tissue array (17 of 25), including TNM, clinical stage, pathology grade and IHC markers (ER, PR, Her-2) results,104 cases/208 cores

Breast tumor tissue array (20 of 25)

BR20826 each
EUR 474
Description: Breast tumor tissue array (20 of 25), including TNM, clinical stage, pathology grade and IHC markers (ER, PR, Her-2) results,104 cases/208 cores

Breast tumor tissue array (3 of 5)

BR20834a each
EUR 546
Description: Breast tumor tissue array (3 of 5), including pathology grade, TNM and clinical stage, 208 cases/208 cores, replacing BR20834

Esophageal inflammation

ES803 each
EUR 270
Description: Esophageal inflammation, hyperplasia and atypical hyperplasia tissue array, 80 cases/80 cores

Brain tumor tissue array of glioblastoma

GL803c each
EUR 306
Description: Brain tumor tissue array of glioblastoma, astrocytoma, ependymoma, oligo astrocytoma, medulloblastoma and oligodendroglioma;80 cases/80 cores (core size 1.5mm), replacing GL803b

Soft tissue tumor tissue array with normal tissue as control

SO481 each
EUR 198
Description: Soft tissue tumor tissue array with normal tissue as control, including TNM and clinical stage, 48 cases/48 cores

Non-Hodgkin's lymphoma tumor tissue array

NHL483 each
EUR 306
Description: Non-Hodgkin's lymphoma tumor tissue array, 48 cases/48 cores

Head and neck tumor tissue array with normal tissue

HN811b each
EUR 258
Description: Head and neck tumor tissue array with normal tissue, including TNM, clinical stage and pathology grade, 27 cases/81 cores, replacing HN811a

Brain tumor with brain tissue array

BS17016d each
EUR 306
Description: Brain tumor with brain tissue array, including pathology grade, 40 cases/80 cores.

Brain tumor with brain tissue array

GL701a each
EUR 234
Description: Brain tumor with brain tissue array, including pathology grade, TNM and clinical stage, 35 cases/70 cores, replacing GL701

Brain tumor and normal tissue array

GL721 each
EUR 306
Description: Brain tumor and normal tissue array, including pathology grade, 24 cases/72 cores

Brain tumor with brain tissue array

GL807a each
EUR 306
Description: Brain tumor with brain tissue array, including pathology grade, 40 cases/80 cores, replacing GL807

Brain tumor and normal tissue array

GL1002 each
EUR 306
Description: Brain tumor and normal tissue array, 50 cases/100 cores

Brain tumor and normal tissue array

GL1201 each
EUR 330
Description: Brain tumor and normal tissue array, including Meningioma and Astrocytoma, Oligodendroglioma, Glioblastoma, Neurilemmoma, Medulloblastoma, Ependymoma, lymphoma, Choroids plexus papilloma, Pituitary adenoma, Germ cell tumours, Acoustic neuroma, craniopharyngioma, Haemangioblastoma, Primal neuroectodermal tumor, with pathology grade, 120 cases/120 cores (core size 1.5mm),replacing BC17013

Brain tumor with brain tissue array

T175c each
EUR 66
Description: Brain tumor with brain tissue array, including pathology grade, 12 cases/24 cores, replacing T175b

Liver tumor with liver tissue array

T032d each
EUR 48
Description: Liver tumor with liver tissue array, including pathology grade, TNM and clinical stage, 12 cases/24 cores, replacing T032c

Human Esophageal Cancer

HS0037 6 Slides/Pack
EUR 160

Testis tumor with testis tissue array

BC23011a each
EUR 270
Description: Testis tumor with testis tissue array, including TNM and clinical stage (reference AJCC 8th version), 24 cases/72 cores, replacing BC23011

Bone and cartilage tumor tissue array with bone tissue

BO481a each
EUR 198
Description: Bone and cartilage tumor tissue array with bone tissue, including TNM and clinical stage, 48 cores/48 cases, replacing BO481

Female reproductive system tumor tissue array

FE951 each
EUR 354
Description: Female reproductive system tumor tissue array, including pathology grade, TNM and clinical stage (AJCC 8.0), 95 cases/95 cores (core size 1.5mm), Recent Year Collection

Testis tumor tissue array with normal tissue as control

T231b each
EUR 48
Description: Testis tumor tissue array with normal tissue as control, including TNM and clinical stage, 6 cases/24 cores, replacing T231a

Kidney tumor tissue array with normal tissue as control

KD961 each
EUR 258
Description: Kidney tumor tissue array with normal tissue as control, including TNM, clinical stage and pathology grade, 48 cases/96 cores

Ovarian tumor with normal tissue array

OV244 each
EUR 66
Description: Ovarian tumor with normal tissue array, including TNM and clinical stage (AJCC 8.0), 12 cases/24 cores (core size 1.5mm)

Soft tissue tumor with adjacent normal tissue array

SO241 each
EUR 66
Description: Soft tissue tumor with adjacent normal tissue array, including TNM and clinical stage, 12 cases/24 cores

Stomach tumor with stomach tissue test tissue array

T012b each
EUR 66
Description: Stomach tumor with stomach tissue test tissue array, including pathology grade, TNM and clinical stage, 12 cases/24 cores, replacing T012a

Brain tumor tissue array with adjacent normal brain tissue

GL241b each
EUR 48
Description: Brain tumor tissue array with adjacent normal brain tissue, including pathology grade, 12 cases/24 cores, replacing GL241a

Mesentery primarily malignant tumor tissue array

MY801 each
EUR 474
Description: Mesentery primarily malignant tumor tissue array, 40 cases/80 cores

Cerebrum tumor with cerebrum tissue array

GL481a each
EUR 168
Description: Cerebrum tumor with cerebrum tissue array, including glioblastoma and astrocytoma, pathology grade, 48 cases/48 cores (core size 1.5mm), replacing GL481

Pancreas tumor with pancreas tissue array

T143b each
EUR 66
Description: Pancreas tumor with pancreas tissue array, including TNM and clinical stage, 6 cases/24 cores, replacing T143a

Leave a Reply

Your email address will not be published. Required fields are marked *